The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.

推荐稀释比 FC:1/50-1/100;ELISA:1/10000

Flow Cytometry analysis of HL-60 cells using CCR2 antibody (green) and negative control (red).

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.