The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

推荐稀释比 WB:1/500-1/1000;FC:1/50-1/100

Western blot analysis of VAV1 (5E7) in Jurkat lysates using VAV1 (5E7) antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。