This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

推荐稀释比 WB:1/500-1/1000;IF:1/50-1/200;FC:1/50-1/100;ELISA:1/10000

Western blot analysis of TRIB2 in Jurkat (1), MCF-7 (2), SW480 (3),and A375 (4) cell lysate using TRIB2 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。