The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene, such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

推荐稀释比 FC:1/50-1/100;ELISA:1/10000

ELISA plate precoated by 1 μg/ml (100 μl/well) Human TNFSF12 protein, hFc tagged protein can bind Rabbit antiTNFSF12 monoclonal antibody in a linear range of 5200 ng/ml.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。