Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) .

推荐稀释比 WB:1/500-1/1000

Western blot analysis of KCTD21 in mouse brain, rat brain lysates using KCTD21 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。