Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP . During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC . Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane . Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing .

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Western blot analysis of DOCK8 in Ramos lysates using DOCK8 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。