The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Western blot analysis of MLK3 in HepG2, A431 lysates using MLK3 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。