Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed .

推荐稀释比 WB:1/500-1/1000;IF:1/50-1/200;IP:1/20

Immunocytochemistry analysis of SESN2 (green) in Hela using SESN2 antibody,and DAPI(blue).

Western blot analysis of SESN2 in mouse spleen, C6 lysates using SESN2 antibody.

Western blot analysis of SESN2 in K562 lysates using SESN2 antibody

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。