Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Immunocytochemistry analysis of Semaphorin 4D (green) in Jurkat using Semaphorin 4D antibody,and DAPI(blue).

Western blot analysis of Semaphorin 4D/CD100 in Jurkat lysates using Semaphorin 4D/CD100 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。