Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200

Immunocytochemistry analysis of HIF1AN (green) in HT-1080 using HIF1AN antibody,and DAPI(blue).

Western blot analysis of HIF1AN/FIH1 in Hela, A549, HL-60, U2OS, U87-MG lysates using HIF1AN/FIH1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue using HIF1AN/FIH1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。