DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity . Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) .

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Immunocytochemistry analysis of Aprataxin (green) in U87-MG using Aprataxin antibody,and DAPI(blue).

Western blot analysis of Aprataxin in K562, Hela lysates using Aprataxin antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。