Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

推荐稀释比 WB:1/500-1/1000;FC:1/50-1/100

Western blot analysis of TCF3 in A431 lysates using Transcription Factor 7 Like 1 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。