Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

推荐稀释比 WB:1/500-1/1000;IF:1/50-1/200;IP:1/20

Immunocytochemistry analysis of APC (green) in LNcap using APC antibody,and DAPI(blue).

Western blot analysis of APC in Hela, A549, HL-60, U2OS lysates using APC antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。