Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200;ELISA:1/10000

Western blot analysis of HEXIM1 in rat HEART lysates using HEXIM1 antibody.

Immunofluorescence analysis of HEXIM1 in HeLa using HEXIM1 antibody. The picture on the right is blocked using the synthesized peptide.

Western blot analysis of HEXIM1 in NIH/3T3 lysates using HEXIM1 antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of HEXIM1 in theHeLa lysates using HEXIM1 antibody

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。