Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

推荐稀释比 WB:1/500-1/1000

Western blot analysis of DLC1 in 293T, DU145, SKOV-3, HT-29 lysates using DLC1 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。