The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of HNF 1 alpha in Human kidney, rat liver, mouse liver and A172 lysates using HNF 1 alpha antibody

Immunohistochemistry analysis of paraffin-embedded Human esophagus cancer using HNF 1 alpha antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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