The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200

Western blot analysis of NR0B2 in various cell lines lysates using NR0B2 antibody.

Immunohistochemistry analysis of paraffin-embedded rat liver using NR0B2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescence analysis of NR0B2 in U2OS cells using NRB2 antibody,and DAPI (blue).

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。