The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of CD130 in 293T, COLO lysates using CD130 antibody.

Immunohistochemistry analysis of paraffin-embedded human brain using CD130 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Sample with blocking peptide on the right.

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