The product of CAMK2A (calcium/calmodulin dependent protein kinase II alpha) belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for CAMK2A.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200;ELISA:1/10000

Western blot analysis of CaMKII alpha/delta in NIH3T3/K562 lysates using CaMKII alpha/delta antibody.

Immunofluorescence analysis of CaMKII alpha/delta in MCF-7 using CaMK2 alpha/delta antibody. The picture on the right is blocked using the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded Human brain tissue using CaMK2 alpha/delta antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.

Western blot analysis of CaMKII alpha/delta in NIH/3T3 and K562 lysates using CaMKII alpha/delta antibody.The lane on the right is blocked with the synthesized peptide.

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