PTRH2 (peptidyl-tRNA hydrolase 2), also known as BIT1 (Bcl-2 inhibitor of transcription 1), is a 179 amino acid mitochondrial protein. During apoptosis, PTRH2 is released from the mitochondia to the cytoplasm. Once in the cytoplasm, PTRH2 regulates the function of two transcriptional regulators, TLE5 and TLE1, thereby promoting caspase-independent cell death. It is also believed that the natural substrate for PTRH2 may be petidyl-tRNAs, which leave the ribosomes during protein synthesis.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of BIT1 in K562, hepg2, 231, Jurkat, Raji lysates using BIT1 antibody

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using BIT1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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