This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of FBXL4 in LOVO lysates using FBXL4 antibody.

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using FBXL4 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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