Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of PDZ RhoGEF in mouse brain lysates using PDZ RhoGEF antibody

Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer using PDZ RhoGEF antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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