This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of Anthrax Toxin Receptor 1 in Lovo, Human liver cancer lysates using Anthrax Toxin Receptor 1 antibody

Immunohistochemistry analysis of paraffin-embedded Human liver cancer using Anthrax Toxin Receptor 1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。