Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation.

推荐稀释比 WB:1/500-1/1000

Western blot analysis of AF10 in K562 lysates using AF10 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。