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Targeting the CTBP1–CETP axis overcomes ferroptosis resistance in non‐small cell lung cancer by altering lipid accumulation

Yanjie Chen, Heng Wang, Ximin Tan, Chenxi Yan, Fangfang Liu, Shuxuan Deng, Chengyan Wang, Yangchen Xia, Zhaolin Xu, Kongming Wu, Shanshan Huang, Qian Chu

Journal：Clinical and Translational Medicine

IF：7.9

DOI：10.1002/ctm2.70749

PMID：42515937

Published：2026-07-27

research field：肿瘤学癌症代谢分子生物学非编码RNA研究

Abstract

CTBP1‐driven CETP activation orchestrates lipid accumulation to suppress MAPK‐dependent ferroptosis in non‐small cell lung cancer. Repurposing the clinical‐stage CETP inhibitor obicetrapib successfully overcomes this resistance in NSCLC patient‐derived organoids, highlighting a promising translational therapeutic strategy.

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