Targeting the CTBP1–CETP axis overcomes ferroptosis resistance in non‐small cell lung cancer by altering lipid accumulation
Yanjie Chen, Heng Wang, Ximin Tan, Chenxi Yan, Fangfang Liu, Shuxuan Deng, Chengyan Wang, Yangchen Xia, Zhaolin Xu, Kongming Wu, Shanshan Huang, Qian Chu
Journal：Clinical and Translational Medicine
IF：7.9
DOI：10.1002/ctm2.70749
PMID：42515937
Published：2026-07-27
research field：分子生物学医学真菌学微生物学
Abstract
CTBP1‐driven CETP activation orchestrates lipid accumulation to suppress MAPK‐dependent ferroptosis in non‐small cell lung cancer. Repurposing the clinical‐stage CETP inhibitor obicetrapib successfully overcomes this resistance in NSCLC patient‐derived organoids, highlighting a promising translational therapeutic strategy.
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