The Protective Mechanism of Continuous Theta Burst Stimulation in the Acute Phase of Stroke Through Modulation of the Calcineurin/AKT/FOXO1 Signaling Pathway

Pengkun Yang, Haocheng Qin, Bao Zhou, Shenyi Kuang, Meixi Liu, Yi Wu, Peng Yuan, Kewei Yu

Journal：CNS Neuroscience & Therapeutics

IF：6.6

DOI：10.1002/cns.71017

PMID：42417481

Published：2026-07-08

research field：

Abstract

During the acute phase of stroke, excitotoxicity‐induced high intracellular calcium levels trigger neuronal damage, with calcineurin playing a key role in the peri‐infarct region. Continuous transcranial magnetic stimulation (cTBS) reduces calcineurin expression, activates the AKT/FOXO1 pathway, and decreases FOXO1 binding at the FasL promoter, mitigating extrinsic apoptosis and offering a novel strategy for neuroprotection after stroke.

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