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The Protective Mechanism of Continuous Theta Burst Stimulation in the Acute Phase of Stroke Through Modulation of the Calcineurin/AKT/FOXO1 Signaling Pathway
Pengkun Yang, Haocheng Qin, Bao Zhou, Shenyi Kuang, Meixi Liu, Yi Wu, Peng Yuan, Kewei Yu
Journal：CNS Neuroscience & Therapeutics
IF：6.6
DOI：10.1002/cns.71017
PMID：42417481
Published：2026-07-08
research field：分子生物学毒理学细胞生物学环境健康金属生物学
Abstract
During the acute phase of stroke, excitotoxicity‐induced high intracellular calcium levels trigger neuronal damage, with calcineurin playing a key role in the peri‐infarct region. Continuous transcranial magnetic stimulation (cTBS) reduces calcineurin expression, activates the AKT/FOXO1 pathway, and decreases FOXO1 binding at the FasL promoter, mitigating extrinsic apoptosis and offering a novel strategy for neuroprotection after stroke.
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