过氧化物酶HRP标记山羊抗兔IgG抗体|Peroxidase-Conjugated Goat Anti-Rabbit IgG（33101ES）

[ 1 ]Leucine-tRNA-synthetase-2-expressing B cells contribute to colorectal cancer immunoevasion

[ 2 ]Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

[ 3 ]SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

[ 4 ]Copper Sulfide Nanoparticle-Redirected Macrophages for Adoptive Transfer Therapy of Melanoma

[ 5 ]Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer

[ 6 ]Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells

[ 7 ]Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome

[ 8 ]Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy

[ 9 ]Anti-PEG Single-Chain Variable-Fragment Antibody-Assisted In Vivo Process Decoding of PEGylated Nanomedicines

[ 10 ]Spatial-Drug-Laden Protease-Activatable M1 Macrophage System Targets Lung Metastasis and Potentiates Antitumor Immunity

[ 11 ]THUMPD3–TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates

[ 12 ]Highly Tumor-Specific and Long-Acting Iodine-131 Microbeads for Enhanced Treatment of Hepatocellular Carcinoma with Low-Dose Radio-Chemoembolization

[ 13 ]Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity

[ 14 ]H3K4 Methylation Promotes Expression of Mitochondrial Dynamics Regulators to Ensure Oocyte Quality in Mice

[ 15 ]The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway

[ 16 ]Vertebral-specific activation of the CX3CL1/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions

[ 17 ]Clematis Tangutica (Maxim.) Korsh. extracts promote melanogenesis via PKA/CREB activation and multi-cytokine inhibition: A novel dual targeting strategy for vitiligo therapy

[ 18 ]A 5′-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer

[ 19 ]Nod factor receptor complex phosphorylates GmGEF2 to stimulate ROP signaling during nodulation

[ 20 ]Soft substrates promote direct chemical reprogramming of fibroblasts into neurons

[ 21 ]A WEEV 6K viroporin activates MLKL-dependent necroptosis to drive inflammatory injury

[ 22 ]Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression

[ 23 ]Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

[ 24 ]PTPRG as a novel tumor suppressor in Chinese hepatocellular carcinoma via dual inactivation mechanisms: High-frequency mutation and transcriptional down-regulation

[ 25 ]Targeting ATF3-mediated asparagine biosynthesis reverses acquired resistance to KRASG12C inhibitors

[ 26 ]LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis

[ 27 ]Melatonin prevents peri‑implantitis via suppression of TLR4/NF-κB

[ 28 ]Display of receptor-binding domain of SARS-CoV-2 Spike protein variants on the Saccharomyces cerevisiae cell surface

[ 29 ]MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment

[ 30 ]α7nAChR agonist GTS-21 ameliorates sepsis-induced acute kidney injury via MEF2/PGC-1α/HO-1 axis in mice

[ 31 ]Spatial and single-cell transcriptomics reveals senescence-associated changes in MIA-induced ASD male mouse brain

[ 32 ]RBM39 Alters Phosphorylation of c-Jun and Binds to Viral RNA to Promote PRRSV Proliferation

[ 33 ]Micranthin B alleviates metabolic dysfunction-associated steatohepatitis by targeting G3BP1 to improve stress granule-mediated endoplasmic reticulum stress

[ 34 ]Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA

[ 35 ]Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1

[ 36 ]Discovery of XYD270 as a Potent, Selective, and Orally Efficacious BRD9 PROTAC for Cancer Therapy

[ 37 ]Discovery of Novel MDH2 Inhibitor 28i by Secondary Development of Glibenclamide with Potent Antiaging Activities

[ 38 ]Discovery of Highly Potent and Selective SOS1 Inhibitors for the Treatment of KRAS-Driven Colorectal Cancer

[ 39 ]Discovery of a Highly Potent and Efficient BRD9 Degrader with Strong In Vivo Antitumor Activity

[ 40 ]Human CYP enzyme-activated genotoxicity of 2,2′,4,4′-tetrabromobiphenyl ether in mammalian cells

[ 41 ]Discovery of precision targeting EZH2 degraders for triple-negative breast cancer

[ 42 ]Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury

[ 43 ]Icariin attenuates endothelial-mesenchymal transition via H19/miR-148b-3p/ELF5 in ox-LDL-stimulated HUVECs

[ 44 ]Fibroblasts as key effectors of acupuncture in treatment of rheumatoid arthritis

[ 45 ]Bartonella type IV secretion effector BepC induces stress fiber formation through activation of GEF-H1

[ 46 ]Spermidine alleviates 2,2-dichloroacetamide/ 2,2-dibromoacetamide-exposed mouse oocyte toxicity by restoring autophagic homeostasis

[ 47 ]Apigenin remodels the gut microbiota to ameliorate ulcerative colitis.

[ 48 ]C8orf76 Modulates Ferroptosis in Liver Cancer via Transcriptionally Up-Regulating SLC7A11

[ 49 ]Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice

[ 50 ]Discovery of PT-65 as a highly potent and selective Proteolysis-targeting chimera degrader of GSK3 for treating Alzheimer's disease

[ 51 ]Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer’s disease

[ 52 ]Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis

[ 53 ]Recruitment of Muscle Genes as an Effect of Brown Adipose Tissue Ablation in Cold-Acclimated Brandt’s Voles (Lasiopodomys brandtii)

[ 54 ]Characterization of Dense Granule Metalloproteinase INS-16 in Cryptosporidium parvum

[ 55 ]Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling

[ 56 ]Evolutionarily conserved odorant-binding proteins participate in establishing tritrophic interactions

[ 57 ]Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity

[ 58 ]Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-related protein-1 targeting strategy

[ 59 ]Drug repurposing of glucosamine to ameliorate alcoholic liver disease and delay liver aging through activation of AMPK signaling pathway

[ 60 ]Preliminary Characterization of Two Small Insulinase-Like Proteases in Cryptosporidium parvum

[ 61 ]Dihydroartemisinin-ursodeoxycholic acid conjugate is a potential treatment agent for inflammatory bowel disease

[ 62 ]FABP5 attenuates pulmonary fibrosis by regulating lipid metabolism in type II alveolar epithelial cells

[ 63 ]Vicatia thibetica de Boiss Crude Polysaccharide Delay the Aging of the Heart and Kidneys

[ 64 ]Liver-specific gene therapy based on self-complementary adeno-associated virus for lysosomal acid lipase deficiency

[ 65 ]MDM2 inhibitor APG-115 exerts potent antitumor activity and synergizes with standard-of-care agents in preclinical acute myeloid leukemia models

[ 66 ]Berbamine reduces body weight via suppression of small GTPase Rab8a activity and activation of paraventricular hypothalamic neurons in obese mice

[ 67 ]Anti-hypertrophic effect of synovium-derived stromal cells on costal chondrocytes promotes cartilage repairs

[ 68 ]Comparative Characterization of CpCDPK1 and CpCDPK9, Two Potential Drug Targets Against Cryptosporidiosis

[ 69 ]MONNA alleviates MPTP-induced Parkinson’s disease in zebrafish by activating TFEB dependently on ER Calcium

[ 70 ]AMPK/mTOR Pathway Is Involved in Autophagy Induced by Magnesium-Incorporated TiO2 Surface to Promote BMSC Osteogenic Differentiation

[ 71 ]Rosmarinic acid regulated purine metabolism to alleviate septic-associated encephalopathy by regulating RRM2

[ 72 ]RNF26 Bridges ER Stress and Autophagy in the Clearance of MERS Envelope protein

[ 73 ]Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells

[ 74 ]Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells

[ 75 ]MiR-92b-3p promotes neurite growth and functional recovery via the PTEN/AKT pathway in acute spinal cord injury

[ 76 ]A Tumor Microenvironment Destroyer for Efficient Cancer Suppression

[ 77 ]Targeting TatD nuclease and the MAPK Pathway: Luteolin multifaceted approach against Mycoplasma gallisepticum infection

[ 78 ]Inferring latent temporal progression and regulatory networks from cross-sectional transcriptomic data of cancer samples

[ 79 ]Comparative genomics analyses reveal sequence determinants underlying interspecies variations in injury-responsive enhancers

[ 80 ]Recombinant hemagglutinin protein and DNA-RNA-combined nucleic acid vaccines harbored by yeast elicit protective immunity against H9N2 avian influenza infection

[ 81 ]Magnetic nanoparticle carrying verbascoside suppresses oral squamous cell carcinoma progression by targeting ICAM1 via IL-6/STAT3 axis

[ 82 ]Differential Expression of Three Cryptosporidium Species-Specific MEDLE Proteins

[ 83 ]Characterization of a Species-Specific Insulinase-Like Protease in Cryptosporidium parvum

[ 84 ]Characterization of cellular senescence in doxorubicin-induced aging mice

[ 85 ]FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia

[ 86 ]PDK1-mediated PI3K/Akt signaling regulates metabolic and developmental programs in a cosmopolitan pest

[ 87 ]Generation of Human Lens Epithelial-Like Cells From Patient-Specific Induced Pluripotent Stem Cells

[ 88 ]Altered expression of ferroptosis markers and iron metabolism reveals a potential role of ferroptosis in vitiligo

[ 89 ]Lysine demethylase 1B (Kdm1b) enhances somatic reprogramming through inducing pluripotent gene expression and promoting cell proliferation

[ 90 ]Selenium attenuates ischemia/reperfusion injury‑induced damage to the blood‑brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway‑mediated autophagy inhibition

[ 91 ]LncRNA H19 Mitigates Oxidized Low-Density Lipoprotein Induced Pyroptosis via Caspase-1 in Raw 264.7 Cells

[ 92 ]Accumulation of Intracellular Ferrous Iron in Inflammatory-Activated Macrophages

[ 93 ]OsHDA710-Mediated Histone Deacetylation Regulates Callus Formation of Rice Mature Embryo

[ 94 ]β-defensin-3 promoted osteosarcoma progression via activating the PI3K/AKT pathway and regulated tumor immune response

[ 95 ]OsCDC48/48E complex is required for plant survival in rice (Oryza sativa L.)

[ 96 ]Ghrelin attenuates drowning injury via dual effects on damage protection and immune repression

[ 97 ]Synthesis and biological evaluation of 1,2,4-oxadiazole core derivatives as potential neuroprotectants against acute ischemic stroke

[ 98 ]The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment

[ 99 ]IL‑6 plays a crucial role in epithelial‑mesenchymal transition and pro‑metastasis induced by sorafenib in liver cancer

[ 100 ]miR-455-5p regulates circadian rhythms by accelerating the degradation of Clock mRNA