Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway
Zehua Ye, Yuqi Xia, Lei Li, BoJun Li, Wu Chen, Shangting Han, Xiangjun Zhou, Lijia Chen, Weimin Yu, Yuan Ruan, Fan Cheng
Journal：Translational Oncology
IF：4.8
DOI：10.1016/j.tranon.2022.101578
PMID：
Published：2022-11-11
research field：肿瘤学分子生物学细胞生物学
Abstract
Highlights • TMEM100 expression was shown to decrease in PCa patients, and low TMEM100 expression was associated with tumor stage and metastasis.• Overexpression of TMEM100 suppressed PCa progression by inhibiting the FAK/PI3K/AKT signaling pathway.• TMEM100 could regulate SCNN1D by inhibiting FAK/PI3K/AKT signaling in PCa cell lines.
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