Large-Scale Synthesis of Glutathione-Coated and 68Ga- Labeled Gold Nanoclusters for PET/CT Imaging of Tumors
Ben Chao Zheng, Qing He Wu, Chun Fu Zhang
Journal：KEY ENGINEERING MATERIALS
IF：0
DOI：10.4028/www.scientific.net/KEM.904.322
PMID：
Published：2021-11-22
research field：肿瘤学癌症研究医学成像放射学呼吸生物学纳米技术
Abstract
Gold nanoclusters (AuNCs) have gained popular attention in recent years because of their efficient tumor accumulation through EPR effect and renal clearance. In this work, we put forward a new approach to prepare glutathione-coated, 68Ga-labeled AuNCs (68Ga-GHS@AuNCs) with ultrasmall sizes (< 2 nm) for PET/CT imaging of tumors. GHS@AuNCs has low cytotoxicity in vitro. PET/CT imaging revealed that the 68Ga-GHS@AuNCs could target tumor and be cleared by kidney efficiently. Our study demonstrates that 68Ga-GHS@AuNCs has great potential for detection of tumors.
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