Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection
Bikash Ranjan Giri, Guofeng Cheng
Journal：INTERNATIONAL JOURNAL FOR PARASITOLOGY
IF：3.48
DOI：10.1016/j.ijpara.2019.08.002
PMID：
Published：2019-11-11
research field：分子生物学免疫学寄生虫学微生物学
Abstract
Extracellular vesicles (EVs) are critical regulators of host-parasite interactions. We previously demonstrated that Schistosoma japonicum EVs contain a remarkably high abundance of host miR-148a. Here, we characterized the abundance of miR-148a in circulation, in peripheral immune cells, and in plasma EVs of S. japonicum-infected mice. The results suggested the high abundance of miR-148a in macrophages to be likely linked to S. japonicum EVs (SjEVs) Additionally, miR-148a was found to target PTEN through the PI3K/AKT pathway to regulate cytokine production in macrophages. Consequently, our findings suggest that high abundance of miR-148a in macrophages may be associated with S. japonicum EVs, and regulate the host immune response during schistosome infection.
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