IL-2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells
Yu-Xi Zhou, Xin Wang, Dan Tang, Yan Li, Ying-Fu Jiao, Yu Gan, Xiao-Ming Hu, Li-Qun Yang, Wei-Feng Yu, Ruth Anne Stetler, Pei-Ying Li, Da-Xiang Wen
Journal：CNS Neuroscience & Therapeutics
IF：3.5
DOI：10.1111/cns.13084
PMID：
Published：2018-11-15
research field：神经科学免疫学
Abstract
Demyelination, one of the major pathological changes of white matter injury, is closely related to T‐cell–mediated immune responses. Thus, we investigate the role of an IL‐2 monoclonal antibody (IL‐2mAb, JES6‐1) in combatting demyelination during the late phase of stroke.
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