Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice
Bao-Shu Xie, Yi-Qin Wang, Yong Lin, Qing Mao, Jun-Feng Feng, Guo-Yi Gao, Ji-Yao Jiang
Journal：CNS Neuroscience & Therapeutics
IF：3.5
DOI：10.1111/cns.13069
PMID：
Published：2018-09-28
research field：神经科学创伤外科药理学细胞生物学干细胞生物学生物化学
Abstract
Ferroptosis, a new form of iron‐dependent programmed cell death, has been shown to be involved in a range of diseases. However, the role of ferroptosis in traumatic brain injury (TBI) has yet to be elucidated. We aimed to investigate whether ferroptosis is induced after TBI and whether the inhibition of ferroptosis would protect against traumatic brain injury in a controlled cortical impact injury (CCI) mouse model.
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