Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage
Bing Wu, Jian-yu Feng, Li-ming Yu, Yan-chun Wang, Yong-qing Chen, Yan Wei, Jin-song Han, Xiao Feng, Yu Zhang, Shou-yin Di, Zhi-qiang Ma, Chong-xi Fan, Xiao-qin Ha
Journal：BRITISH JOURNAL OF PHARMACOLOGY
IF：6.81
DOI：10.1111/bph.14457
PMID：
Published：2018-07-26
research field：分子生物学药理学细胞生物学心脏病学生物化学
Abstract
Icariin, a major active ingredient in traditional Chinese medicines, is attracting increasing attention because of its unique pharmacological effects against ischaemic heart disease. The histone deacetylase, sirtuin‐1, plays a protective role in ischaemia/reperfusion (I/R) injury, and this study was designed to investigate the protective role of icariin in models of cardiac I/R injury and to elucidate the potential involvement of sirtuin‐1.
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