X-ray examination of a tissue-engineered epithelial sheet during transportation
Xiaomin Shao, Fuyue Wu, Zheng Lin Tan
Journal：Frontiers in Bioengineering and Biotechnology
IF：5.8
DOI：10.3389/fbioe.2026.1764810
PMID：41852783
Published：2026-03-03
research field：辐射生物学生物医学工程转化研究再生医学组织工程
Abstract
Autologous tissue-engineered epithelial sheets (TEESs) are generally transported by dedicated couriers. The cost of this technology can be reduced by using cold-chain courier services, in which the TEESs are subjected to X-rays during security checks. We exposed TEESs to a widely used X-ray luggage-control system to the maximum dose limited by regional regulations. DNA fragmentation, unique variants by exome sequencing, and proliferative capabilities were not altered after X-ray exposure. Thus, repeated exposure to X-ray radiation of luggage-control systems did not induce changes in TEESs genetically or biologically, which should simplify the transport of grafts.
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