Perflubron (Perfluorooctyl bromide)是一种磁共振与超声成像用造影剂,常与卵磷脂（EYP）乳化以加速排泄。该化合物具有抗炎、抗病毒及细胞保护作用,其机制涉及抑制趋化因子表达和NF-κB活化。
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英文别名 (English Synonym) |
Perflubron |
|
中文名称 (Chinese Name) |
全氟辛基溴 |
|
靶点 (Target) |
Immunology & Inflammation related |
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通路 (Pathway) |
Immunology/Inflammation |
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CAS号 (CAS NO.) |
423-55-2 |
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分子式 (Formula) |
C8BrF17 |
|
分子量 (Molecular Weight) |
498.96 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于EtOH |
-25~-15℃保存，有效期3年
[1] Woods CM, Neslund G, Kornbrust E, Flaim SF. Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2000 May,278(5):L1008-17. doi: 10.1152/ajplung.2000.278.5.L1008. PMID: 10781432.[2]Haeberle HA, Nesti F, Dieterich HJ, Gatalica Z, Garofalo RP. Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappa B activation. Am J Respir Crit Care Med. 2002 May 15,165(10):1433-8. doi: 10.1164/rccm.2109077. PMID: 12016108.
