Felbinac是芬布芬的口服有效活性代谢物,作为一种非甾体抗炎剂,它通过抑制COX减少前列腺素生成,从而发挥解热镇痛抗炎作用,并能抑制CHIKV病毒活性。
|
英文别名 (English Synonym) |
Felbinac |
|
中文名称 (Chinese Name) |
4-联苯乙酸 |
|
靶点 (Target) |
Immunology & Inflammation related |
|
通路 (Pathway) |
Immunology/Inflammation |
|
CAS号 (CAS NO.) |
5728-52-9 |
|
分子式 (Formula) |
C14H12O2 |
|
分子量 (Molecular Weight) |
212.24 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Kasabe B, Ahire G, Patil P, Punekar M, Davuluri KS, Kakade M, Alagarasu K, Parashar D, Cherian S. Drug repurposing approach against chikungunya virus: an in vitro and in silico study. Front Cell Infect Microbiol. 2023 Apr 27,13:1132538. doi: 10.3389/fcimb.2023.1132538. Erratum in: Front Cell Infect Microbiol. 2023 Jun 23,13:1226054. doi: 10.3389/fcimb.2023.1226054. PMID: 37180434, PMCID: PMC10174255.[2]Kasuya F, Miwa Y, Kazumi M, Inoue H, Ohta H. Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues. Int J Toxicol. 2011 May,30(3):367-76. doi: 10.1177/1091581810397619. Epub 2011 Jun 1. PMID: 21633127.
