Dimethyl Fumarate是一种口服有效的Nrf2通路激活剂，能够穿透血脑屏障并诱导抗氧化基因表达上调。它通过耗竭GSH、升高ROS及激活MAPKs途径诱导肿瘤细胞坏死与自噬，临床上用于复发-缓解型多发性硬化症的治疗。
| 英文别名 (English Synonym) | Dimethyl Fumarate |
| 中文名称 (Chinese Name) | 富马酸二甲酯 |
| 靶点 (Target) | KEAP1-Nrf2 |
| 通路 (Pathway) | Immunology/Inflammation |
| CAS号 (CAS NO.) | 624-49-7 |
| 分子式 (Formula) | C6H8O4 |
| 分子量 (Molecular Weight) | 144.13 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Xie X, Zhao Y, Ma CY, Xu XM, Zhang YQ, Wang CG, Jin J, Shen X, Gao JL, Li N, Sun ZJ, Dong DL. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015 Aug;172(15):3929-43. doi: 10.1111/bph.13184. Epub 2015 Jun 12. PMID: 25953698; PMCID: PMC4523346.
[2] Jing X, Shi H, Zhang C, Ren M, Han M, Wei X, Zhang X, Lou H. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40. doi: 10.1016/j.neuroscience.2014.11.047. Epub 2014 Nov 29. PMID: 25449120.
