甲羟孕酮是一种口服有效的合成孕激素，作为孕酮受体激动剂，可通过激活PI3K/Akt信号通路促进细胞增殖，并在小鼠模型中显示出抗动脉粥样硬化活性。其受体激动活性弱于其乙酰化衍生物——醋酸甲羟孕酮。
|
英文别名 (English Synonym) |
Medroxyprogesterone |
|
中文名称 (Chinese Name) |
甲羟孕酮；甲孕酮 |
|
靶点 (Target) |
Estrogen/progestogen Receptor |
|
通路 (Pathway) |
Endocrinology and Hormones |
|
CAS号 (CAS NO.) |
520-85-4 |
|
分子式 (Formula) |
C22H32O3 |
|
分子量 (Molecular Weight) |
344.49 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Ito F, Tatsumi H, Mori T, Suganuma I, Tanaka Y, Sasaki A, Matsuo S, Iwasa K, Kitawaki J. Medroxyprogesterone acetate enhances monocyte-endothelial interaction under flow conditions by stimulating the expression of cell adhesion molecules. J Clin Endocrinol Metab. 2014 Jun;99(6):2188-97. doi: 10.1210/jc.2013-2925. Epub 2014 Feb 25. PMID: 24606071.[2]Freudenberger T, Oppermann M, Marzoll A, Heim HK, Mayer P, Kojda G, Weber AA, Schrör K, Fischer JW. Differential effects of medroxyprogesterone acetate on thrombosis and atherosclerosis in mice. Br J Pharmacol. 2009 Dec;158(8):1951-60. doi: 10.1111/j.1476-5381.2009.00470.x. PMID: 20050187; PMCID: PMC2807657.
