Risperidone (R-64766, R64766),又称利哌酮、利培酮、瑞司哌酮、瑞斯哌东、利哌利酮、利司环酮或利司培酮,苯并异恶唑衍生物,抗精神病药物,是选择性单胺能拮抗剂,作用于5-HT2A和dopamine D2受体的Ki值分别为4.8、5.9 nM。利培酮可用于治疗精神分裂症。
参考文献
1.Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl). 1993;110(3):265-72.
2.Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12(1):197-204.
3.Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32(4):757-64.
4.Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21(3):259-67.
冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。