Bisindolylmaleimide IV双吲哚马来酰亚胺IV是蛋白激酶C (PKC)的细胞渗透抑制剂，IC₅₀值为0.10~0.55 μM，能够抑制蛋白激酶A，IC₅₀值范围为2~11.8 μM。Bisindolylmaleimide IV可能通过PKC/NF-κB/c-Fos途径逆转高葡萄糖对心肌细胞的影响，具有促凋亡的作用。

参考文献

[1] Davis, P. D., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides. Journal of Medicinal Chemistry 35, 177-184 (1992).

[2] Toullec, D. , et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. The Journal of Biological Chemisty 266(24), 15771-15781 (1991).

[3] Zhang, W.  B. et al. Reverse effect of protein kinase C inhibitor Ro-31-8220 on the hypertrophy of cardiomyocytes of neonatal rats induced by high glucose levels. Chinese Journal of Pathophysiology. 2009-08.

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