The Interleukin 17B (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus . With the exception of IL-17B, which exists as a noncovalently linked dimer, all IL-17 family members are disulfide-linked dimers . IL-17 family proteins are pro?inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Two receptors (IL?17 R, and IL-17B R), which are activated by IL-17 family members, have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL?17 RE, have also been reported. Human IL-17B cDNA encodes a 180 aa protein with a putative 20 aa signal peptide. Human and mouse IL-17B share 88% amino acid sequence identity. Among IL-17 family members, IL-17B is most closely related to IL-17D, sharing 27% aa sequence homology. IL-17B is expressed highly in spinal cord, and at lower levels in brain, kidney, lung, small intestine, prostate, testes, pancreas, adrenal gland and trachea (5?7). Expression of IL-17B has also been detected in chondrocytes in articular cartilage. IL-17B binds the IL-17B receptor but not IL-17 R and exhibits bioactivities distinct from those of IL-17.

高纯度、高活性、低内毒素、高批间一致性

-25 ~ -15℃保存，收到货之后有效期1年。 复溶后，无菌条件下，2~8℃保存，7天有效期。复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。