R-spondin3 is a member of the R-spondin family of secreted proteins that play crucial roles in regulating Wnt/β-catenin signaling pathway. R-spondin3 is known to enhance Wnt signaling by binding to the LGR4-6 receptors, leading to the stabilization of the Wnt receptor complex and promoting the nuclear translocation of β-catenin. This results in the activation of Wnt target genes involved in various cellular processes such as proliferation, differentiation, and stem cell maintenance. R-spondin3 has been implicated in embryonic development, tissue homeostasis, and regeneration, as well as in the pathogenesis of certain diseases, including cancer.

高活性、高纯度、低内毒素、高批间一致性

ELISA Data: Measured by its binding ability in a functional ELISA. When Recombinant Mouse RNF43 mFC Chimera, is immobilized 2µg/mL (100 µl/well), Recombinant Mouse R-spondin3/RSPO3 His Tag binds with an EC50 of 0.02-0.036μg/ml.

-25 ~ -15℃保存，收到货之后有效期1年。复溶后， 2 ~ 8 °C保存，7 天有效期。复溶后， -85 ~ -65℃保存，3个月有效期。建议首次使用时将蛋白等分，避免重复冻融循环。