盐酸伊塔诺塞替尼（Itacnosertib hydrochloride，代号TP-0184 hydrochloride）是FLT3、ACVR1（又称ALK2，IC50=8纳摩尔/升）和JAK2（IC50=8540纳摩尔/升）的抑制剂，具有抗白血病活性。

[1] Tyagi A, Jaggupilli A, Ly S, Yuan B, El-Dana F, Hegde VL, Anand V, Kumar B, Puppala M, Yin Z, Wong STC, Mollard A, Vankayalapati H, Foulks JM, Warner SL, Daver N, Borthakur G, Battula VL. TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax. Leukemia. 2024 Jan;38(1):82-95. doi: 10.1038/s41375-023-02086-6. Epub 2023 Nov 25. PMID: 38007585.