Fuzapladib sodium（IS-741）是口服有效的双重抑制剂，既能抑制白细胞功能相关抗原1（LFA-1，白细胞粘附分子）激活，也能抑制磷脂酶A2（PLA2），通过阻止白细胞向炎症部位迁移发挥抗炎作用。

[1] Shikama H, Yotsuya S, Satake S, Sugi H, Kato M. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Biol Pharm Bull. 1999 Feb;22(2):127-31. doi: 10.1248/bpb.22.127. PMID: 10077429.[2]Fukunaga T, Tsujikawa T, Sasaki M, Fujiyama Y, Bamba T, Fujimiya M. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid. J Gastroenterol. 2003;38(5):451-9. doi: 10.1007/s00535-002-1081-8. PMID: 12768387.