Sparstolonin B是一种天然化合物,能双重抑制TLR2和TLR4受体,有效阻断其介导的炎症通路,并展现出抗HIV与抗癌的潜力。
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-25~-15℃避光保存,有效期3年。
[1] Kumar A, Fan D, Dipette DJ, Singh US. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells. PLoS One. 2014 May 1;9(5):e96343. doi: 10.1371/journal.pone.0096343. Erratum in: PLoS One. 2016 Jul 6;11(7):e0159082. doi: 10.1371/journal.pone.0159082. PMID: 24788776; PMCID: PMC4006872.
[2] Liang Q, Wu Q, Jiang J, Duan J, Wang C, Smith MD, Lu H, Wang Q, Nagarkatti P, Fan D. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011 Jul 29;286(30):26470-9. doi: 10.1074/jbc.M111.227934. Epub 2011 Jun 10. PMID: 21665946; PMCID: PMC3143611.





