LXW7是一种高亲和力的整合素αvβ3抑制剂,该环状肽含有RGD序列。它能增强VEGFR-2磷酸化与ERK1/2活化,并具有抗炎活性。
[1] Xiao W, Wang Y, Lau EY, Luo J, Yao N, Shi C, Meza L, Tseng H, Maeda Y, Kumaresan P, Liu R, Lightstone FC, Takada Y, Lam KS. The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct;9(10):2714-23. doi: 10.1158/1535-7163.MCT-10-0308. Epub 2010 Sep 21. PMID: 20858725; PMCID: PMC3571112.[2]Fang T, Zhou D, Lu L, Tong X, Wu J, Yi L. LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats. Braz J Med Biol Res. 2016 Aug 1;49(9):e5287. doi: 10.1590/1414-431X20165287. PMID: 27533766; PMCID: PMC4988477.





