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基于框架引导组装策略的反义DNA递送与可控释放研究
Delivery and controllable release of anti-sense DNA based on frame-guided assembly strategy
Ya-nan Zhang, Ximei Hou, Jiafang Piao, Wei Yuan, Bi-ni Zhou, Xiaoping Zhao, Ziyang Hao, Yuan Zhuang, Lijin Xu, Yuanchen Dong, Dongsheng Liu
Journal：EUROPEAN POLYMER JOURNAL
IF：5.55
DOI：10.1016/j.eurpolymj.2022.111187
PMID：
Published：2022-05-04
research field：化学工程微流控技术材料科学生物技术
Abstract
Using nanoparticles to deliver antisense oligonucleotides is a fabulous way which can solve the difficulty of penetrating cell membrane on account of high molecular weight and high negative charges. Herein, we have reported a frame-guided assembly strategy to prepare drug delivery system for anti-sense DNA. The in vitro experiments demonstrated that the anti-sense oligonucleotides vesicles perform good cytotoxicity to the cancer cells by downregulation of the expression of anti-apoptotic Bcl-2 gene, finally resulting in the apoptosis. It is feasible that taking advantage of the programmable assembly process and good stability of the frame-guided assembly (FGA) systems, this strategy can deliver a wide variety of drugs.
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