An Engineered Design of Self-Assembly Nanomedicine Guided by Molecular Dynamic Simulation for Photodynamic and Hypoxia-Directed Therapy
Yu Wang, Haotian Zhang, Jianwei Wang, Guping Tang, Hongzhen Bai
Journal：MOLECULAR PHARMACEUTICS
IF：4.9
DOI：10.1021/acs.molpharmaceut.2c01079
PMID：36848620
Published：2023-02-27
research field：分子生物学基因治疗生物药剂学药物递送纳米医学
Abstract
To overcome the hypoxia barrier in tumor therapy, a hypoxia-activated prodrug of docetaxel (DTX-PNB) was synthesized and self-assembled with indocyanine green (ICG), forming a combination nanomedicine ISDNN. With the guidance of molecular dynamic simulation, the ISDNN construction could be accurately controlled, achieving uniform size distribution and high drug loading up to 90%. Within the hypoxic tumor environment, ISDNN exerted ICG-mediated photodynamic therapy and aggravated hypoxia to boost DTX-PNB activation for chemotherapy, enabling enhanced antitumor efficacy.
本文使用的Yeasen产品
