TCF4 contributes to OA progression by regulating the transcription of LOXL1
Wang Jiquan, Liu Xiaojun, Fan Xinyi, Zhang Yiming, Ouyang Haiyang
Journal：Journal of Inflammation-London
IF：4.1
DOI：10.1186/s12950-026-00494-w
PMID：
Published：2026-03-18
research field：分子生物学风湿病学遗传学
Abstract
Highlights LOXL1 is highly expressed in tissues and cells of OA. Silencing LOXL1 mitigates IL-1β-induced chondrocyte damage and MIA-induced joint pathology in mice. TCF4 stimulates the transcription of LOXL1. LOXL1 abrogates the impacts of TCF4 deletion in chondrocytes induced by IL-1β. Supplementary Information The online version contains supplementary material available at 10.1186/s12950-026-00494-w.
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