Abstract

Stress urine incontinence (SUI) affects women's physical, mental, and social health. The minimally invasive periurethral injection of hyaluronic acid-based hydrogels has gained popularity for urethral support and continence. SUI therapy is tried using novel hyaluronic acid-based hydrogels loaded with ginsenoside Rb1 (HB-Rb1). It has good biocompatibility, mechanical strength, and swelling ratio. The hydrogel's cytocompatibility and good cellular adhesion in L929 cells suggested it could reduce inflammation and assist tissue regeneration. In mice with SUI, HB-Rb1 improved the local microenvironment, collagen deposition, and urethral tissue regeneration, relieving SUI symptoms. H&E staining assessed histological alterations. The results demonstrate that HB-Rb1 can treat SUI and that nursing care is essential. Long-term efficacy and clinical translation of advanced biomaterials and nursing-led care in women's health should be the focus of future study.